Determination of neutrophil antigen HNA-3a and HNA-3b genotype frequencies in six racial groups by high-throughput 5′ exonuclease assay
نویسندگان
چکیده
منابع مشابه
Identification of the HNA-3a antigen.
Among the 5 HNA systems, HNA-3 was the only one that had yet to be characterized. This effort was critical because antibodies directed to HNA-3a are responsible for causing numerous cases of transfusion-related acute lung injury (TRALI), especially fatal TRALI.2-4 Antibodies to HNA-3a cause neutrophil (PMN) agglutination, priming of the PMN oxidase, and PMN-mediated killing of pulmonary endothe...
متن کاملNeutrophil antigen (FcgammaRIIIB) SH gene frequencies in six racial groups.
Human leukocyte surface receptors specific for the Fc portion of IgG play a critical role in immune function by coupling the humoral and cellular immune systems. The Fcg receptor III (FcRIII) (CD 16), one of three Fc receptor classes, is encoded by two highly homologous genes on chromosome 1.1 FcRIIIA encodes the transmembrane receptor expressed on macrophages and natural killer cells and is no...
متن کاملRisk Estimation of HNA-3 Incompatibility and Alloimmunization in Thai Populations
Severe transfusion-related acute lung injury (TRALI) is often due to antibodies in blood components directed against human neutrophil antigen (HNA)-3a. This study aimed to report the genotype frequencies of the HNA-3 system and to estimate the potential risk of HNA-3 incompatibility and alloimmunization in two Thai populations. Eight hundred DNA samples obtained from 500 unrelated healthy blood...
متن کاملA Case of Neonatal Alloimmune Neutropenia Associated with Anti-Human Neutrophil Antigen-1a (HNA-1a) Antibody
Neonatal alloimmune neutropenia (NAN) is an uncommon disease of the newborn provoked by the maternal production of neutrophil-specific alloantibodies, whereby neutrophil IgG antibodies cross the placenta and induce the destruction of fetal neutrophils. Affected newborns are usually identified by the occurrence of bacterial infections. The most frequent antigens involved in NAN are the human neu...
متن کاملبررسی مولکولی آنتی‌ژن نوتروفیلی – 3 در برخی اهداکنندگان خون
چکیده سابقه و هدف آلوآنتی‌ژن‌های نوتروفیلی در بسیاری از عوارض انتقال خون, نظیر آسیب حاد ریوی پس از انتقال خون, مقاومت به تزریق گرانولوسیت‌ها و واکنش‌های تب‌زای انتقال خون دخالت دارند. به علت عدم وجود گزارش وفور این آنتی‌ژن‌ها، هدف این مطالعه بررسی فراوانیHNA-3a وHNA-3b در برخی اهداکنندگان خون ساکن تهران بود. مواد و روش‌ها در یک مطالعه توصیفی، از تعداد 110 اهداکننده خون مراجعه‌کننده به پایگاه...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Transfusion
سال: 2012
ISSN: 0041-1132
DOI: 10.1111/j.1537-2995.2012.03600.x